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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-NBD-14107
NBD-14107

Chemical Structure : NBD-14107

CAS No.: 2086328-94-9

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NBD-14107 (NBD14107)

货号: PC-70011Not For Human Use, Lab Use Only.

NBD-14107 (NBD14107) potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NBD-14107 (NBD14107) potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction.
    NBD-14107 exhibits antiviral activity against a large panel of HIV-1 Env-pseudotyped viruses representing diverse subtypes of clinical isolates with mean EC50 of 0.49 uM.
    NBD-14107 also inhibits HIV-1 RT with IC50 of 8.4 uM.
    NBD-14107 exhibits improving the potency, toxicity, and ADMET profile compared with NBD-14010.

    物理化学性质&存储条件

    分子量 412.84
    分子式 C17H15ClF2N4O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-amino-1-(5-(hydroxymethyl)thiazol-2-yl)ethyl)-5-(4-chloro-3,5-difluorophenyl)-1H-pyrrole-2-carboxamide

    参考文献

    1. Curreli F, et al. J Med Chem. 2017 Apr 13;60(7):3124-3153.

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