NB-598 | Squalene epoxidase inhibitor | Probechem Biochemicals

Chemical Structure : NB-598

CAS No.: 131060-14-5

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NB-598 (NB598)

货号: PC-23586Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2880	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

NB-598 (NB598) is a potent competitive inhibitor of squalene epoxidase (SQLE, SE, squalene monooxygenase) with IC50 of 4.4 nM (rat SE), inhibits microsomal squalene epoxidase from dog liver and Hep G2 cells with IC50 of 2.0 and 0.75 nM, respectively.
NB-598 also strongly inhibited cholesterol synthesis from [14C]acetate in Hep G2 cells with an ICso value of 3.4 nM.
NB-598 inhibited cholesterol synthesis from [14C]acetate dose dependently in Hep G2 cells and increased the intracellular radioactivity of squalene.
A single oral administration of NB-598 inhibited cholesterol synthesis from [14C]acetate in rats.
Multiple oral administration of NB-598 to dogs decreased serum total and low density lipoprotein cholesterol levels and increased serum squalene levels.

物理化学性质&存储条件

分子量	449.67
分子式	C27H31NOS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenemethanamine, 3-([3,3′-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethyl-

参考文献

1. Nakamura Y, et al. J Biol Chem. 1996 Apr 5;271(14):8053-6.

2. Horie M, et al. J Biol Chem. 1990 Oct 25;265(30):18075-8.

3. Hidaka Y, et al. J Biol Chem. 1991 Jul 15;266(20):13171-7.

NB-598 (NB598)

生物&药学活性

物理化学性质&存储条件

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NB-598 (NB598)

生物&药学活性

物理化学性质&存储条件

参考文献

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