Chemical Structure : NAcM-OPT
CAS No.: 2089293-61-6
货号: PC-61931Not For Human Use, Lab Use Only.
NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥1280 | In stock | |
50 mg | ¥1980 | In stock | |
100 mg | ¥3280 | In stock | |
200 mg | Get quote | ||
1 g | Get quote |
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NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.
NAcM-OPT also inhibits DCN2, but has no activity against DCN3, DCN4, or DCN5.
NAcM-OPT inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.
分子量 | 434.405 | |
分子式 | C23H29Cl2N3O | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea |
1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857.
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