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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Ubiquitin-conjugating Enzyme (E2)-NAcM-OPT
NAcM-OPT

Chemical Structure : NAcM-OPT

CAS No.: 2089293-61-6

NAcM-OPT (DCN1 inhibitor NAcM-OPT)

货号: PC-61931Not For Human Use, Lab Use Only.

NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.

规格 价格 库存 数量
25 mg ¥1280 In stock
50 mg ¥1980 In stock
100 mg ¥3280 In stock
200 mg Get quote
1 g Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.
NAcM-OPT also inhibits DCN2, but has no activity against DCN3, DCN4, or DCN5.
NAcM-OPT inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

物理化学性质&存储条件

分子量 434.405
分子式 C23H29Cl2N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea

参考文献

1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857.

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