NAcM-COV |CAS:2089293-81-0 Probechem Biochemicals

Chemical Structure : NAcM-COV

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NAcM-COV (DCN1 inhibitor NAcM-COV)

货号: PC-61932Not For Human Use, Lab Use Only.

NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays.

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生物&药学活性

NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays.
NAcM-COV shows highly selectivity with respect to other protein acetyl-amide-binding sites.
NAcM-COV inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

物理化学性质&存储条件

分子量	516.609
分子式	C28H35F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((1-(1-(pentan-2-yl)piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)ureido)methyl)phenyl)acrylamide

参考文献

1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857.

NAcM-COV (DCN1 inhibitor NAcM-COV)

生物&药学活性

物理化学性质&存储条件

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NAcM-COV (DCN1 inhibitor NAcM-COV)

生物&药学活性

物理化学性质&存储条件

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