NAPQI |CAS:50700-49-7 Probechem Biochemicals

Chemical Structure : NAPQI

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NAPQI (N-Acetylimidoquinone)

货号: PC-70232Not For Human Use, Lab Use Only.

NAPQI (N-Acetylimidoquinone) is a toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of macrophage migration inhibitory factor (MIF).

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生物&药学活性

NAPQI (N-Acetylimidoquinone) is a toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of macrophage migration inhibitory factor (MIF).
NAPQI inhibits both the isomerase and the biological activities of MIF with IC50 of 40 uM.
NAPQI significantly inhibits the ability of MIF to override the immunosuppressive effect of dexamethasone on endotoxin- (LPS) stimulated TNFα production by monocytes.

物理化学性质&存储条件

分子量	149.147
分子式	C8H7NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide

参考文献

1. Senter PD, et al. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):144-9.

2. Albano E, et al. Mol Pharmacol. 1985 Sep;28(3):306-11.

3. Crichlow GV, et al. Biochemistry. 2009 Jan 13;48(1):132-9.

NAPQI (N-Acetylimidoquinone)

生物&药学活性

物理化学性质&存储条件

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NAPQI (N-Acetylimidoquinone)

生物&药学活性

物理化学性质&存储条件

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