NAMPT activator (NAT-5r) | NAMPT activator | Probechem Biochemicals

Chemical Structure : NAMPT activator (NAT-5r)

CAS No.: 2790481-63-7

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NAMPT activator (NAT-5r) (NAT-5r)

货号: PC-38440Not For Human Use, Lab Use Only.

NAMPT activator (NAT-5r) is a potent, small molecule activator of nicotinamide phosphoribosyltransferase (NAMPT) with ITC KD of 180 nM, 3-fold improved activity over NAT.

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5 mg	￥2380	In stock
10 mg	￥3880	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

NAMPT activator (NAT-5r) is a potent, small molecule activator of nicotinamide phosphoribosyltransferase (NAMPT) with ITC KD of 180 nM, 3-fold improved activity over NAT.
NAMPT activator (NAT-5r) had no effect on NMNAT1 enzyme activity, both NAMPT mutants of K189R and K189A reduced the binding affinity of NAT-5r.
NAMPT activator (NAT-5r) treatment significantly enhanced NAD content in NAMPT-WT cells, but not in NAMPT-CRISPR cells.
Treatment of NAT-5r at 3 μM concentrations for 4 h induced significant elevation of cellular NAD.
NAMPT activator (NAT-5r) induced subsequent metabolic and transcriptional reprogramming, promoted proliferation and maintain the self-renewal of NSCs and protects peripheral sensory neurons from paclitaxel-(PTX) induced damage in mouse model.

物理化学性质&存储条件

分子量	324.380
分子式	C19H20N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(tert-butyl)-6-cyanophenoxy)-N-(4-hydroxyphenyl)acetamide

参考文献

1. Hong Yao, et al. Cell Research (2022) 0:1-15.

NAMPT activator (NAT-5r) (NAT-5r)

生物&药学活性

物理化学性质&存储条件

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NAMPT activator (NAT-5r) (NAT-5r)

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物理化学性质&存储条件

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