NAC1 inhibitor NIC3

Chemical Structure : NAC1 inhibitor NIC3

CAS No.: 494830-67-0

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货号: PC-23404Not For Human Use, Lab Use Only.

NAC1 inhibitor NIC3 is a specific small molecule inhibitor of oncogenic nucleus accumbens-associated protein-1 (NAC1), inhibits NAC1 homodimerization, leading to proteasomal NAC1 degradation.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NAC1 inhibitor NIC3 is a specific small molecule inhibitor of oncogenic nucleus accumbens-associated protein-1 (NAC1), inhibits NAC1 homodimerization, leading to proteasomal NAC1 degradation.
NIC3 binds to the conserved Leu-90 of NAC1 and prevents its homodimerization.
NIC3 accelerates the proteasomal degradation of NAC1 protein.
NIC3 significantly sensitizes drug-resistant tumor cells to cisplatin and Adriamycin in vitro and in vivo.
NIC3 significantly strengthens the therapeutic efficacy of bevacizumab in a metastatic breast cancer mouse model.
NIC3 is able to sensitize mice-bearing NAC1-expressing ovarian tumors to anti-PD-1 therapy.

物理化学性质&存储条件

分子量	440.58
分子式	C26H36N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-(ethane-1,2-diyl)bis(2-(4-(tert-butyl)phenoxy)acetamide)

参考文献

1. Wang X, et al. J Biol Chem. 2019 Jun 21;294(25):10006-10017.

2. Dong S, et al. Cancer Immunol Res. 2024 Nov 12. doi: 10.1158/2326-6066.CIR-24-0084.