NAB-14 |CAS:1237541-73-9 Probechem Biochemicals

Chemical Structure : NAB-14

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NAB-14 (NAB14)

货号: PC-63207Not For Human Use, Lab Use Only.

NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors.

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生物&药学活性

NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors.
NAB-14 inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors.
NAB-14 inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.

物理化学性质&存储条件

分子量	351.406
分子式	C20H21N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((1H-indol-7-yl)carbamoyl)phenyl diethylcarbamate

参考文献

1. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319.

NAB-14 (NAB14)

生物&药学活性

物理化学性质&存储条件

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NAB-14 (NAB14)

生物&药学活性

物理化学性质&存储条件

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