NA-184 | Calpain-2 inhibitor | Probechem Biochemicals

Chemical Structure : NA-184

加入收藏

NA-184 (NA184)

货号: PC-21909Not For Human Use, Lab Use Only.

NA-184 is a potent, selective calpain-2 inhibitor with Ki of 50 nM (human calpain-2) and IC50 of 134 nM (mouse calpain-2).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NA-184 is a potent, selective calpain-2 inhibitor with Ki of 50 nM (human calpain-2) and IC50 of 134 nM (mouse calpain-2).
NA-184 displays 20-fold selective over mouse calpain-1 (IC50=2826 nM).
NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases at concentrations up to 10 μM, with exception of cathepsin L and B (Ki=1.9 and 220 nM).
NA-184 inhibits TBI-induced calpain-2 activation and cell death in mice and rats, both male and females.
NA-184 exhibites properties, including stability in plasma and liver and blood–brain barrier permeability.

物理化学性质&存储条件

分子量	531.05
分子式	C27H35ClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-(3-benzylureido)-N-(1-((3-chloro-2-methoxybenzyl)amino)-1,2-dioxopentan-3-yl)-4-methylpentanamide

参考文献

1. Baudry M, et al. Pharmacol Res Perspect. 2024 Apr;12(2):e1181.

NA-184 (NA184)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NA-184 (NA184)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.