N6F11

Chemical Structure : N6F11

CAS No.: 851398-76-0

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货号: PC-28755Not For Human Use, Lab Use Only.

N6F11 is a ferroptosis inducer and tumor-specificglutathione peroxidase 4 (GPX4) degrader, selectively induces ferroptosis by targeting TRIM25-mediated GPX4 degradation.

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10 mg	￥580	In stock
25 mg	￥880	In stock
50 mg	￥1280	In stock
100 mg		Get quote

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生物&药学活性

N6F11 is a ferroptosis inducer and tumor-specificglutathione peroxidase 4 (GPX4) degrader, selectively induces ferroptosis by targeting TRIM25-mediated GPX4 degradation.
N6F11 does not cause the degradation of GPX4 in immune cells, including dendritic, T, natural killer, and neutrophil cells.
N6F11 binds the RING domain of E3 ubiquitin ligase tripartite motif containing 25 (TRIM25) in cancer cells to trigger TRIM25-mediated K48-linked ubiquitination of GPX4, resulting in its proteasomal degradation.
N6F11 treatment caused ferroptotic cancer cell death that initiated HMGB1-dependent antitumor immunity mediated by CD8+ T cells.
N6F11 also sensitized immune checkpoint blockade that targeted CD274/PD-L1 in advanced cancer models, including genetically engineered mouse models of pancreatic cancer driven by KRAS and TP53 mutations.

物理化学性质&存储条件

分子量	311.18
分子式	C13H8Cl2N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(Chloromethyl)-6-(4-chlorophenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one

参考文献

1. Li J, et al. Sci Transl Med. 2023 Nov;15(720):eadg3049.

N6F11

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N6F11

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