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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Ubiquitin-activating Enzyme (E1)-N106
N106

Chemical Structure : N106

CAS No.: 862974-25-2

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N106 (SUMO-activating enzyme E1 ligase activator)

货号: PC-27148Not For Human Use, Lab Use Only.

N106 is a specific small molecule activaotor of SUMOylation of SERCA2a, directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

N106 is a specific small molecule activaotor of SUMOylation of SERCA2a, directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.
N106 increases SERCA2a's cellular activity and SUMOylation in adult cardiomyocytes. increased SERCA2a ATPase activity and levels of SERCA2a SUMOylation in cardiomyocytes.
N106 does not significantly stimulate any in-vitro activity of the ubiquitin-activating enzyme (Ub E1) at concentrations up to 100 μM, including ubiquitin activation, conjugation of ubiquitin to Ub E1 enzyme and Ub E1-dependent conjugation of ubiquitin to the E2 enzyme cdc32.
N106 is specific for SUMO E1 enzyme.
N106 treatment (0.1, 1.0 and 10 mg/ kg) increases contractile properties of cultured rat cardiomyocytes and significantly improves ventricular function in mice with heart failure.

物理化学性质&存储条件

分子量 354.38
分子式 C17H14N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Methoxybenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine

参考文献

1. Changwon Kho, et al. Nat Commun. 2015 Jun 12;6:7229.

2. Xu H, et al. Gene. 2024 Nov 15;927:148740.

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