N1-hexyl-N5-benzyl-biguanide mesylate (HBB) | CYP3A4 inhibitor

Chemical Structure : N1-hexyl-N5-benzyl-biguanide mesylate

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N1-hexyl-N5-benzyl-biguanide mesylate (CYP3A4 inhibitor HBB)

货号: PC-61908Not For Human Use, Lab Use Only.

N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis.

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生物&药学活性

N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis.
HBB displays significantly higher for CYP2C8 (IC50=45 uM), and does not inhibit the AA epoxygenase activity of CYP2J2.
HBB inhibits MCF-7 cell line and ER+ and triple-negative breast cancer cell lines with similar IC50 (20 uM).
HBB strongly inhibits the oxygen consumption rate (OCR) and suppresses ATP stores, rapidly activates pAMPK and inhibits Stat3, mTOR, and ERK.
HBB inhibits MCF-7 xenograft tumor growth (24 mg/kg/week i.p.).

物理化学性质&存储条件

分子量	371.5
分子式	C16H29N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-hexyl-N5-benzyl-biguanide mesylate

参考文献

1. Guo Z, et al. Cell Chem Biol. 2017 Oct 19;24(10):1259-1275.e6.

N1-hexyl-N5-benzyl-biguanide mesylate (CYP3A4 inhibitor HBB)

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N1-hexyl-N5-benzyl-biguanide mesylate (CYP3A4 inhibitor HBB)

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