N.41 |CAS:357441-99-7 Probechem Biochemicals

Chemical Structure : N.41

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N.41 (HIV inhibitor N.41; Vif inhibitor N.41)

货号: PC-60887Not For Human Use, Lab Use Only.

N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).

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生物&药学活性

N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).
N.41 shows potent antiviral activity in A3G(+) but not in A3G(-) T cells with IC50 of 8.4 uM and TC50 of >100 uM against HIV-1Ba-L replication in peripheral blood mononuclear cells.
N.41 inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner.

物理化学性质&存储条件

分子量	254.289
分子式	C15H14N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-hydroxyphenyl)amino)-1-(pyridin-3-yl)but-2-en-1-one

参考文献

1. Pery E, et al. J Biol Chem. 2015 Apr 17;290(16):10504-17.

N.41 (HIV inhibitor N.41; Vif inhibitor N.41)

生物&药学活性

物理化学性质&存储条件

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N.41 (HIV inhibitor N.41; Vif inhibitor N.41)

生物&药学活性

物理化学性质&存储条件

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