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N-Acetyl-Calicheamicin

Chemical Structure : N-Acetyl-Calicheamicin

CAS No.: 108212-76-6

N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ;N-Acetyl-γ-calicheamicin)

货号: PC-45713Not For Human Use, Lab Use Only.

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic.

规格 价格 库存 数量
10 mg Get quote
50 mg Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic; targets DNA and causes strand scission; a ADC payload in antibody drug conjugates development.

物理化学性质&存储条件

分子量 1410.385
分子式 C57H76IN3O22S4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Carbamic acid, [(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyrano

参考文献

1. Stasi R, et al. Cancer Treat Rev. 2008 Feb;34(1):49-60.

2. Naito K, et al. Leukemia. 2000 Aug;14(8):1436-43.

3. Hills RK, et al. Lancet Oncol. 2014 Aug;15(9):986-96.

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