Mz325 | Sirt2/HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : Mz325

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Mz325 (Mz 325)

货号: PC-21304Not For Human Use, Lab Use Only.

Mz325 is a potent, selective, dual inhibitor of Sirt2/HDAC6 with IC50 of 320/43 nM, respectively.

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生物&药学活性

Mz325 is a potent, selective, dual inhibitor of Sirt2/HDAC6 with IC50 of 320/43 nM, respectively.
Mz325 displays no inhibitory acitvities against Sirt1 and Sirt3, shows little activity against HDAC1/2/3 (IC50=2-6 uM).
Mz325 (20 μM) increases α-tubulin acetylation levels in PC-3M-luc prostate cancer cells.
Mz325 can induce dual inhibition of the tubulin deacetylases Sirt2 and HDAC6 on a cellular level.
Mz325 reduces the viability of a panel of solid cancer cell lines of different chemosensitivity and tissue origin, including HGC27 gastric carcinoma cells, W1 ovarian cancer cells, MCF-7 breast cancer cells, and PC-3M-luc prostate cancer cells.

物理化学性质&存储条件

分子量	771.96
分子式	C38H45N9O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((N-butyl-5-(4-((3-((2-(2-((4,6-dimethylpyrimidin-2-yl)thio)acetamido)thiazol-5-yl)methyl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentanamido)methyl)-N-hydroxybenzamide

参考文献

1. Laura Sinatra, et al. J Med Chem. 2023 Oct 30. doi: 10.1021/acs.jmedchem.3c01385.

Mz325 (Mz 325)

生物&药学活性

物理化学性质&存储条件

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Mz325 (Mz 325)

生物&药学活性

物理化学性质&存储条件

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