Myosin inhibitor F10

Chemical Structure : Myosin inhibitor F10

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货号: PC-21413Not For Human Use, Lab Use Only.

Cardiac-myosin inhibitor F10 is a cardiac-myosin specific and allosteric inhibitor with IC50 of 23 uM on actomyosin ATPase activity.

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生物&药学活性

Cardiac-myosin inhibitor F10 is a cardiac-myosin specific and allosteric inhibitor with IC50 of 23 uM on actomyosin ATPase activity.
F10 reduces the maximum rate of ATP hydrolysis, does not affect the affinity of myosin S1 for F-actin per se.
F10 (20 uM) significantly reduces the ATPase activity of fully Ca2+-activated cardiac myofibrils by about 25% but has no effect on the ATPase of myofibrils isolated from fast skeletal muscle, F10 is a MYH7/6-specific inhibitor.
F10 slows nucleotide release from bovine β-cardiac myosin. can stabilize both its biochemical and structural OFF state.
F10 reduces both isometric force and its calcium sensitivity in isolated muscle fibers and acts as a negative inotrope in Langendorff-perfused hearts.

物理化学性质&存储条件

分子量	296.41
分子式	C12H16N4OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(6-ethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)-3-isopropylthiourea

参考文献

1. Priyanka Parijat, et al. Nat Commun. 2023 Nov 24;14(1):7692.