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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-Myomed-946
Myomed-946

Chemical Structure : Myomed-946

CAS No.: 852863-80-0

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Myomed-946 (ID#704946, Myomed 946)

货号: PC-38107Not For Human Use, Lab Use Only.

MyoMed-946 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MyoMed-946 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.
    MyoMed-946 inhibits MuRF1 expression/activity in vivo and is able to attenuate skeletal muscle atrophy and dysfunction in mice treated with monocrotaline to induce right ventricular hypertrophy and subsequent cardiac cachexia.
    MyoMed-946 attenuates skeletal muscle strength loss in mouse model for type 2 diabetes mellitus (T2DM), with no significant effects on serum glucose.
    MyoMed-946 attenuates induction of MuRF1 in tumor stressed muscles.
    MyoMed-946 also rescues citrate synthase and complex-1 activities in tumor-stressed muscles.
    MuRF1 (muscle-specific RING finger protein-1) is a muscle-specific ubiquitin ligase that regulates muscle catabolism during chronic wasting states, both MuRF1 and MuRF2 participate in glucose and, also, in lipid regulation.

    物理化学性质&存储条件

    分子量 490.468
    分子式 C26H22N2O8
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3-(furan-2-ylmethyl)ureido)-2-oxoethyl 4-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)benzoate

    参考文献

    1. Eva Zaccariotto, et al. J Cachexia Sarcopenia Muscle. 2022 Mar 17.

    2. Adams V, et al. Cells. 2020 Oct 11;9(10):2272.

    3. Labeit S, et al. Int J Mol Sci. 2021 Feb 23;22(4):2225.

    4. Bowen TS, et al. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.

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