Myokinasib |MLCK1 inhibitor| Probechem Biochemicals

Chemical Structure : Myokinasib

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Myokinasib

货号: PC-36046Not For Human Use, Lab Use Only.

Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex.

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生物&药学活性

Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex.
Myokinasib inhibits only two additional kinases PLK2/3 with IC50 of 10.3/6.7 uM in a panel of 25 kinases, does not bind to the Polo-box domain of PLK2 and PLK3.
Myokinasib impairs cytokinesis, induces formation of multinucleated cells, and reduces phosphorylated myosin II light chain abundance on stress fibers, reduces phospho-S19-MLC protein levels in cells.

物理化学性质&存储条件

分子量	402.538
分子式	C26H30N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (6R,7R,8S,9R)-8-(2,6-dimethylphenyl)-6,7-dimethyl-6,7,8,10-tetrahydro-6,9-epiminocyclohepta[b]indole-9(5H)-carboxylate

参考文献

1. Schneidewind T, et al. Cell Chem Biol. 2018 Dec 11. pii: S2451-9456(18)30436-7.

Myokinasib

生物&药学活性

物理化学性质&存储条件

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Myokinasib

生物&药学活性

物理化学性质&存储条件

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