Myokinasib-II

Chemical Structure : Myokinasib-II

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货号: PC-23164Not For Human Use, Lab Use Only.

Myokinasib-II is a potent and highly selective myosin light-chain kinase (MLCK) chemical probe inhibitor with IC50 of 4.4 uM for MLCK-1.

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生物&药学活性

Myokinasib-II is a potent and highly selective myosin light-chain kinase (MLCK) chemical probe inhibitor with IC50 of 4.4 uM for MLCK1.
Myokinasib-II displays better potency, better selectivity profile, and no nonspecific interference in relevant assays as compared to other known MLCK inhibitors.

物理化学性质&存储条件

分子量	437.47
分子式	C24H24FN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (6R,7R,8R,9R)-8-(4-fluoro-2-methylphenyl)-6-methyl-7-nitro-6,7,8,10-tetrahydro-6,9-epiminocyclohepta[b]indole-9(5H)-carboxylate

参考文献

1. Gautam Kumar, et al. ACS Chem Biol. 2024 Sep 20. doi: 10.1021/acschembio.4c00336.

Myokinasib-II

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物理化学性质&存储条件

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Myokinasib-II

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物理化学性质&存储条件

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