MyoMed-205 |CAS:2614161-13-4 Probechem Biochemicals

Chemical Structure : MyoMed-205

CAS No.: 2614161-13-4

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MyoMed-205 (MyoMed205, MyoMed 205)

货号: PC-38106Not For Human Use, Lab Use Only.

MyoMed-205 is a small molecule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MyoMed-205 is a small molecule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.
MyoMed-205 has improved serum stability when compared with initial lead compound ID#704946.
MyoMed-205 attenuates induction of MuRF1 in tumor stressed muscles. MyoMed-205 also rescues citrate synthase and complex-1 activities in tumor-stressed muscles.
MyoMed-205 attenuates skeletal muscle strength loss in mouse model for type 2 diabetes mellitus (T2DM), with no significant effects on serum glucose.
MuRF1 (muscle-specific RING finger protein-1) is a muscle-specific ubiquitin ligase that regulates muscle catabolism during chronic wasting states, both MuRF1 and MuRF2 participate in glucose and, also, in lipid regulation.

物理化学性质&存储条件

分子量	491.562
分子式	C26H25N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[(4-Methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]methyl]-N-[2-[[[(2-thienylmethyl)amino]carbonyl]amino]ethyl]benzamide

参考文献

1. Eva Zaccariotto, et al. J Cachexia Sarcopenia Muscle. 2022 Mar 17.

2. Adams V, et al. Cells. 2020 Oct 11;9(10):2272.

3. Labeit S, et al. Int J Mol Sci. 2021 Feb 23;22(4):2225.

4. Bowen TS, et al. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.

MyoMed-205 (MyoMed205, MyoMed 205)

生物&药学活性

物理化学性质&存储条件

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MyoMed-205 (MyoMed205, MyoMed 205)

生物&药学活性

物理化学性质&存储条件

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