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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-c-Myc-Mycro3
Mycro3

Chemical Structure : Mycro3

CAS No.: 944547-46-0

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Mycro3 (Myc/Max dimerization inhibitor)

货号: PC-38503Not For Human Use, Lab Use Only.

Mycro3 is a selective small molecule inhibitor of Myc/Max dimerization with IC50 of 40 uM with a cognate-binding site, inhibits DNA binding of c-Myc with preference over other dimeric transcription factors in vitro.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mycro3 is a selective small molecule inhibitor of Myc/Max dimerization with IC50 of 40 uM with a cognate-binding site, inhibits DNA binding of c-Myc with preference over other dimeric transcription factors in vitro.
Mycro3 inhibits c-Myc-dependent proliferation, gene transcription, and oncogenic transformation in the low micromolar concentration range.
Mycro3 inhibits c-Myc-dependent gene transcription and c-Myc-dependent anchorage-independent growth.
Mycro3 drastically attenuated in Mycro3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells.

物理化学性质&存储条件

分子量 526.88
分子式 C24H17ClF2N6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Ethyl 5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-1H-pyrazole-4-carboxylate

参考文献

1. Bonham AJ, et al. Nucleic Acids Res. 2013 Jan;41(2):754-63.

2. Stellas D, et al. J Natl Cancer Inst. 2014 Oct 11;106(12):dju320.

3. Anke Kiessling, et al. Chem Biol. 2006 Jul;13(7):745-51.

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