Mycro2 | c-Myc inhibitor | Probechem Biochemicals

Chemical Structure : Mycro2

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Mycro2 (c-Myc/Max dimerization inhibitor)

货号: PC-23436Not For Human Use, Lab Use Only.

Mycro2 is a selective small molecule inhibitor of c-Myc/Max dimerization with IC50 of 23 uM, inhibits c-Myc dependent transcription.

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100 mg		Get quote

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生物&药学活性

Mycro2 is a selective small molecule inhibitor of c-Myc/Max dimerization with IC50 of 23 uM, inhibits c-Myc dependent transcription.
Mycro2 inhibits the protein-protein interactions between CFP-tagged c-Myc and GST-tagged Max in a GST pull-down assay.
Mycro2 inhibits DNA binding of c-Myc with preference over other dimeric transcription factors in vitro.
Mycro2 inhibits c-Myc-dependent proliferation, gene transcription, and oncogenic transformation in the low micromolar concentration range.
Mycro2 inhibits c-Myc-dependent cell proliferation and delays S-Phase entry.

物理化学性质&存储条件

分子量	408.42
分子式	C17H11F3N4OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-thiophen-2-yl-N-(thiophen-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

参考文献

1. Kiessling A, et al. Chem Biol. 2006 Jul;13(7):745-51.

Mycro2 (c-Myc/Max dimerization inhibitor)

生物&药学活性

物理化学性质&存储条件

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Mycro2 (c-Myc/Max dimerization inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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