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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-GABA Receptor-Muscimol
Muscimol

Chemical Structure : Muscimol

CAS No.: 2763-96-4

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Muscimol (Agarin, Agarine)

货号: PC-23986Not For Human Use, Lab Use Only.

Muscimol (Agarin) is a psychoactive isoxazole and selective neurotransmitter GABA agonist, binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with EC50 of 200 nM, also is a small molecule inhibitor of ninjurin-1 (NINJ1) oligomerization and NINJ1 mediated membrane rupture.

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10 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Muscimol (Agarin) is a psychoactive isoxazole and selective neurotransmitter GABA agonist, binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with EC50 of 200 nM, also is a small molecule inhibitor of ninjurin-1 (NINJ1) oligomerization and NINJ1 mediated membrane rupture.

物理化学性质&存储条件

分子量 114.10
分子式 C4H6N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(aminomethyl)-1,2-oxazol-3-one

参考文献

1. S M Dunn, et al. 1994 Jan 25;33(3):755-63.

2. den Hartigh AB, et al. Commun Biol. 2023 Oct 5;6(1):1010.

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