Murepavadin TFA | Antibiotic, MRGPRX2 agonist | Probechem Biochemicals

Chemical Structure : Murepavadin TFA

CAS No.:

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Murepavadin TFA (POL7080, POL-7080)

货号: PC-28263Not For Human Use, Lab Use Only.

Murepavadin TFA (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
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生物&药学活性

Murepavadin TFA (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.
Murepavadin displays antibacterial activity against a broad panel of multi-drug-resistant P. aeruginosa.
Murepavadin induces Ca2+ mobilization, degranulation, chemokine IL-8 and CCL3 production in a human MC line (LAD2 cells) endogenously expressing MRGPRX2.
Murepavadin activates human MCs via MRGPRX2 and murine MCs via MrgprB2 and that MRGPRX2 is resistant to β-arrestin-mediated receptor regulation.
activates mast cells via MRGPRX2 and MrgprB2.
Murepavadin shows potential for the treatment of bacterial infections caused by Pseudomonas aeruginosa.

物理化学性质&存储条件

分子量	1667.83
分子式	C73H112N22O16.C2HF3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cyclo[Ala-Ser-D-Pro-Pro-Thr-Trp-Ile-Dab-Orn-D-Dab-Dab-Trp-Dab-Dab] TFA salt

参考文献

1. Bassetti M, et al. Curr Opin Infect Dis. 2018 Jan 13. doi: 10.1097/QCO.0000000000000438.

Murepavadin TFA (POL7080, POL-7080)

生物&药学活性

物理化学性质&存储条件

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Murepavadin TFA (POL7080, POL-7080)

生物&药学活性

物理化学性质&存储条件

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