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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Mufemilast
Mufemilast

Chemical Structure : Mufemilast

CAS No.: 1255909-03-5

Mufemilast (Hemay005)

货号: PC-73431Not For Human Use, Lab Use Only.

Mufemilast (Hemay005) is a potent, selective, first-in-class PDE4 inhibitor with in vitro IC50 of 80-120 nM, exhibits comparable inhibitory activities to apremilast.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Mufemilast (Hemay005) is a potent, selective, first-in-class PDE4 inhibitor with in vitro IC50 of 80-120 nM, exhibits comparable inhibitory activities to apremilast.
    Hemay005 displayed a significant inhibitory effect on TNF-α, which was an important proinflammatory cytokine target in the disease process of psoriasis.
    Hemay005 exhibited a considerable efficacy in psoriasis xenograft SCID mouse model compared with apremilast at the same dose of 20 mg/kg per day in the reduction of psoriasis area and epidermal thickness, protein expression changes and
    histological scores.

    物理化学性质&存储条件

    分子量 466.523
    分子式 C20H22N2O7S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-N-(5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4,6-dioxo-5,6-dihydro-4H-thieno[3,4-c]pyrrol-1-yl)acetamide

    参考文献

    1. Xuemei Liu, et al. Bioanalysis. 2018 Jun 1;10(11):863-875.

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