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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Mtb LepB inhibitor 17af
Mtb LepB inhibitor 17af

Chemical Structure : Mtb LepB inhibitor 17af

CAS No.:

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Mtb LepB inhibitor 17af

货号: PC-25077Not For Human Use, Lab Use Only.

Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb.

物理化学性质&存储条件

分子量 472.49
分子式 C23H19F3N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-amino-6-(6-methoxypyridin-3-yl)-N-(1-phenylethyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Lynde BE, et al. ACS Med Chem Lett. 2025 Jan 3;16(2):241-249.

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