Mtb GpsI inhibitor X1

Chemical Structure : Mtb GpsI inhibitor X1

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货号: PC-24913Not For Human Use, Lab Use Only.

Mtb GpsI inhibitor X1 is a specific small molecule inhibitor of mycobacterial PNPase, guanosine penta-phosphate synthase I (GpsI), with IC50 of 1.95 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Mtb GpsI inhibitor X1 is a specific small molecule inhibitor of mycobacterial PNPase, guanosine penta-phosphate synthase I (GpsI), with IC50 of 1.95 uM.
X1 functions as a noncompetitive inhibitor of Mtb-GpsI, with dissociation constant Ki of 0.79 uM and 0.95 uM for degradation and synthesis of poly(A).
X1 inhibits Mtb-GpsI but not Synechocystis PNPase in a dose-dependent manner.
X1 exhibits potent bactericidal properties, killing 99% of Mtb within 72 h at MIC concentration of 4.4 mg/l (7.8 μM) and within 48 h at two-fold MIC (15.6 μM).
X1 binds to the conserved phosphate-binding pocket and traps the poly(A) substrate.

物理化学性质&存储条件

分子量	563.53
分子式	C30H24F3N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclopentanecarboxylic acid, 1-[[[4′-[[[2-phenyl-5-(trifluoromethyl)-4-oxazolyl]carbonyl]amino][1,1′-biphenyl]-4-yl]carbonyl]amino]-

参考文献

1. Griesser T, et al. Nucleic Acids Res. 2025 Jun 6;53(11):gkaf529.