MtbFadD32 inhibitor M1

Chemical Structure : MtbFadD32 inhibitor M1

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货号: PC-23766Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MtbFadD32 inhibitor M1 is a small molecule inhibitor of Mycobacterium tuberculosis fatty acyl-AMP ligase FadD32 and FadD28, shows specific antitubercular activity with IC50 of 4.8 ug/mL, binds and inhibits the FAAL activity of MtbFadD32 and MtbFadD28 enzymes.
M1 is inactive against E. coli up to 200 μg/mL concentration.
M1 in combination with frontline TB drugs rifampicin (R) and isoniazid (I) exhibited better activity against Mtb than M1 alone.
M1 displays uncompetitive inhibition for MtbFadD32 with respect to lauric acid with Ki of 48.1 uM and partial noncompetitive inhibition for ATP with Ki of 55.3 uM.
M1 (2.5 mg/kg body weight, i.p.) reduces lung-associated mycobacterial burden in chronic model of TB infection.

物理化学性质&存储条件

分子量	386.95
分子式	C10H4Br2F3NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-dibromo-6-[3-(trifluoromethyl)-1,2-oxazol-5-yl]phenol

参考文献

1. Rani N, et al. J Med Chem. 2025 Jan 9;68(1):270-286.