Mps1 inhibitor 2 |CAS:1228817-38-6 Probechem Biochemicals

Chemical Structure : Mps1 inhibitor 2

CAS No.: 1228817-38-6

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Mps1 inhibitor 2 (Mps1-IN-2)

货号: PC-62240Not For Human Use, Lab Use Only.

Mps1 inhibitor 2 (Mps1-IN-2) is a potent, selective Mps1 kinase inhibitor with IC50 of 145 nM, demonstrates >1,000-fold selectivity over a panel of 352 kinases with the major exceptions of Gak and Plk1.

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

Mps1 inhibitor 2 (Mps1-IN-2) is a potent, selective Mps1 kinase inhibitor with IC50 of 145 nM, demonstrates >1,000-fold selectivity over a panel of 352 kinases with the major exceptions of Gak and Plk1.
Mps1-IN-2 treratment leads to defects in Mad1 and Mad2 establishment at unattached kinetochores, decreases Aurora B kinase activity, premature mitotic exit and gross aneuploidy, without any evidence of centrosome duplication defects; decreases cancer cell viability.

物理化学性质&存储条件

分子量	480.613
分子式	C26H36N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-cyclopentyl-2-(2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenylamino)-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

参考文献

1. Kwiatkowski N, et al. Nat Chem Biol. 2010 May;6(5):359-68.

Mps1 inhibitor 2 (Mps1-IN-2)

生物&药学活性

物理化学性质&存储条件

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Mps1 inhibitor 2 (Mps1-IN-2)

生物&药学活性

物理化学性质&存储条件

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