Mpro inhibitor GD-9

Chemical Structure : Mpro inhibitor GD-9

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货号: PC-49579Not For Human Use, Lab Use Only.

Mpro inhibitor GD-9 is a potent, covalent SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.18 uM, exhibits antiviral potency against SARS-CoV-2 with EC50 of 2.64 uM.

规格	价格	库存	数量
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250 mg		Get quote

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生物&药学活性

Mpro inhibitor GD-9 is a potent, covalent SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.18 uM, exhibits antiviral potency against SARS-CoV-2 with EC50 of 2.64 uM.
GD-9 shows similar antiviral potency to that of remdesivir (EC50 = 2.27 μM).
GD-9 presented favorable target selectivity for SARS-CoV-2 Mpro versus human cysteine proteases.

物理化学性质&存储条件

分子量	446.77
分子式	C18H18Cl3N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(2-chloroacetyl)-1-(3,4-dichlorophenyl)-N-(thiophen-2-ylmethyl)piperazine-2-carboxamide

参考文献

1. Gao S, et al. J Med Chem. 2022 Dec 22;65(24):16902-16917.