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首页-抗体和重组蛋白-Biosimilar Antibody-Moxetumomab
Moxetumomab

Chemical Structure : Moxetumomab

CAS No.:

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Moxetumomab (Anti-human CD22 mAb, human IgG1-Kappa)

货号: PC-Ab1113Not For Human Use, Lab Use Only.

Moxetumomab pasudotox is an anti-CD22 monoclonal antibody fused to a 38 kDa fragment of Pseudomonas exotoxin A, PE38. Moxetumomab binds to CD22 on HCL cells and leads to apoptotic cell death after internalization and trafficking of the toxin to the cytosol. CD22 is a single chain integral membrane molecule and a mem­ber of the immunoglobulin gene superfamily, an inhibitory B lymphocyte receptor specifically recognizing α2,6 sialic acids. It functions as an adhesion receptor and a signaling molec

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Moxetumomab pasudotox is an anti-CD22 monoclonal antibody fused to a 38 kDa fragment of Pseudomonas exotoxin A, PE38. Moxetumomab binds to CD22 on HCL cells and leads to apoptotic cell death after internalization and trafficking of the toxin to the cytosol. CD22 is a single chain integral membrane molecule and a mem­ber of the immunoglobulin gene superfamily, an inhibitory B lymphocyte receptor specifically recognizing α2,6 sialic acids. It functions as an adhesion receptor and a signaling molecule, which appears to be involved in regulating the expression of surface IgM on peripheral B-cells and Ca++ flux in response to immunoglobulin signaling.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Moxetumomab; Anti-human CD22; Anti-human Siglec-2; Anti-human sialic acid binding Ig-like lectin 2

参考文献

1. 1, Kreitman RJ, et al. Leukemia. 2018 Aug;32(8):1768-1777. 2, Fancher KM, et al. J Oncol Pharm Pract. 2019 Sep;25(6):1467-1472. 3, Lin AY, et al. Blood Adv. 2019 Oct 8;3(19):2905-2910. 4, Kreitman RJ, et al. J Pharm Sci. 2020 Sep;109(9):2676-2683.

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