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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-Motixafortide
Motixafortide

Chemical Structure : Motixafortide

CAS No.: 664334-36-5

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Motixafortide (BL-8040, BKT-140, TF14016, 4F-Benzoyl-TN14003)

货号: PC-47505Not For Human Use, Lab Use Only.

Motixafortide (BL-8040, BKT-140, TF-14016) is a 14-residue biostable synthetic peptide, high-affinity CXCR4 antagonist (IC50=1 nM).

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5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Motixafortide (BL-8040, BKT-140, TF-14016) is a 14-residue biostable synthetic peptide, high-affinity CXCR4 antagonist (IC50=1 nM).
Motixafortide (BL-8040, BKT-140, TF-14016) inhibits CXCL12-mediated migration of human Jurkat cells and mouse splenocyte in a dose-dependent manner in vitro (IC50=0.65 and 0.54 nM, respectively).
Motixafortide (BL-8040, BKT-140, TF-14016) ameliorates severity in collagen-induced arthritis in mice.

物理化学性质&存储条件

分子量 2159.52
分子式 C97H144FN33O19S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 36 mg/mL
Chemical Name/SMILES

L-Argininamide, N2-(4-fluorobenzoyl)-L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4→13)-disulfide

参考文献

1. Tamamura H, et al. FEBS Lett. 2004 Jul 2;569(1-3):99-104.

2. Peled A, et al. Clin Cancer Res. 2014 Jan 15;20(2):469-79.

3. Beider K, et al. Exp Hematol. 2011 Mar;39(3):282-92.

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