Motesanib diphosphate |CAS:857876-30-3 Probechem Biochemicals

Chemical Structure : Motesanib diphosphate

CAS No.: 857876-30-3

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Motesanib diphosphate (AMG-706, AMG706)

货号: PC-42472Not For Human Use, Lab Use Only.

Motesanib diphosphate (AMG706) is a potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.

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50 mg	￥1280	In stock
100 mg	￥1980	In stock
250 mg	￥3280	In stock
1 g		Get quote

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生物&药学活性

Motesanib diphosphate (AMG706) is a potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.
Motesanib also displays activity against Ret (IC50=59 nM), no activities against EGFR, Src, and p38.
Motesanib inhibits human endothelial cell proliferation induced by VEGF, but not by bFGF in vitro; potently inhibits VEGF-induced angiogenesis in the rat models.

物理化学性质&存储条件

分子量	569.4413
分子式	C22H29N5O9P2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-, phosphate (1:2)

参考文献

1. Polverino A, et al. Cancer Res. 2006 Sep 1;66(17):8715-21.

2. Sherman SI, et al. N Engl J Med. 2008 Jul 3;359(1):31-42.

3. Coxon A, et al. Clin Cancer Res. 2009 Jan 1;15(1):110-8.

4. Caenepeel S, et al. J Exp Clin Cancer Res. 2010 Jul 15;29:96.

Motesanib diphosphate (AMG-706, AMG706)

生物&药学活性

物理化学性质&存储条件

参考文献

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Motesanib diphosphate (AMG-706, AMG706)

生物&药学活性

物理化学性质&存储条件

参考文献

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