Motesanib | VEGFR inhibitor Probechem Biochemicals

Chemical Structure : Motesanib

CAS No.: 453562-69-1

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Motesanib (AMG706, AMG-706)

货号: PC-42471Not For Human Use, Lab Use Only.

Motesanib (AMG706) is a potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥880	In stock
50 mg	￥1280	In stock
100 mg	￥1980	In stock
250 mg		Get quote

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生物&药学活性

Motesanib (AMG706) is a potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.
Motesanib (AMG706) also displays activity against Ret (IC50=59 nM), no activities against EGFR, Src, and p38.
Motesanib (AMG706) inhibits human endothelial cell proliferation induced by VEGF, but not by bFGF in vitro.
Motesanib (AMG706) potently inhibits VEGF-induced angiogenesis in the rat models.

物理化学性质&存储条件

分子量	373.4509
分子式	C22H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-

参考文献

1. Polverino A, et al. Cancer Res. 2006 Sep 1;66(17):8715-21.

2. Sherman SI, et al. N Engl J Med. 2008 Jul 3;359(1):31-42.

3. Coxon A, et al. Clin Cancer Res. 2009 Jan 1;15(1):110-8.

4. Caenepeel S, et al. J Exp Clin Cancer Res. 2010 Jul 15;29:96.

Motesanib (AMG706, AMG-706)

生物&药学活性

物理化学性质&存储条件

参考文献

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Motesanib (AMG706, AMG-706)

生物&药学活性

物理化学性质&存储条件

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