Mortaparib Plus

Chemical Structure : Mortaparib Plus

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货号: PC-49357Not For Human Use, Lab Use Only.

Morataprib Plus is a novel anticancer small molecule that disrupts mortalin-p53 interaction, prevents the interaction of mortalin with p53 resulting in the activation of growth arrest and apoptosis mediated by activation of p21WAF1 or BAX and PUMA signalling, respectively.

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生物&药学活性

Morataprib Plus is a novel anticancer small molecule that disrupts mortalin-p53 interaction, prevents the interaction of mortalin with p53 resulting in the activation of growth arrest and apoptosis mediated by activation of p21WAF1 or BAX and PUMA signalling, respectively.
MortaparibPlus-induced cytotoxicity to cancer cells is mediated by multiple mechanisms that included the inhibition of PARP1, up-regulation of p73, and also the down-regulation of mortalin and CARF proteins that play critical roles in carcinogenesis.

物理化学性质&存储条件

分子量	287.326
分子式	C17H13N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(1E)-2-(2-phenylindol-3-yl)-1-azavinyl]-1,2,4-triazole

参考文献

1. Sari AN, et al. Cancers (Basel). 2021 Feb 17;13(4):835.

2. Meidinna HN, et al. Front Cell Dev Biol. 2022 Sep 12;10:918970.

Mortaparib Plus

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Mortaparib Plus

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