Mortaparib

Chemical Structure : Mortaparib

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货号: PC-49356Not For Human Use, Lab Use Only.

Mortaparib is a dual inhibitor of mortalin-PARP1 interaction, and a p53 activating cytotoxic compound, induces activation of growth arrest and apoptosis signaling in cancer cells in vitro and in vivo.

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生物&药学活性

Mortaparib is a dual inhibitor of mortalin-PARP1 interaction, and a p53 activating cytotoxic compound, induces activation of growth arrest and apoptosis signaling in cancer cells in vitro and in vivo.
Mortaparib is toxic in the range of 2–5 μM in HeLa, ME180, SKG-II and SKG-IIIb (cervical cancer), SKOV-3 and OVK18 (ovarian cancer) cells.
Mortaparib-treated cells showed p53-mediated growth arrest and apoptosis, showed decrease in anti-apoptotic proteins: Bcl-2, COX-1, COX-IV and Procaspase-3, -7 and -9.
Mortaparib caused inhibition of PARP1 and activation of DNA damage stress signaling in HeLa cells.
Mortaparib-treated (20 mg/kg body weight) mice showed suppression of tumor growth in subcutaneous xenografts of SKOV-3 cells; and was not toxic to mice.

物理化学性质&存储条件

分子量	345.366
分子式	C18H15N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[1-(4-methoxyphenyl)(1,2,3,4-tetraazol-5-yl)]-4-phenylpyrimidine-2-ylamine

参考文献

1. Jayarani F Putri, et al. J Exp Clin Cancer Res. 2019 Dec 19;38(1):499.

Mortaparib

生物&药学活性

物理化学性质&存储条件

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Mortaparib

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