Morncide | p53-Morn3 inhibitor | Probechem Biochemicals

Chemical Structure : Morncide

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Morncide (CPP-Morn3 (222-237))

货号: PC-49198Not For Human Use, Lab Use Only.

Morncide (Morn3 (222-237)) is a cell-penetrating, 16-AA Morn3-targeting peptide that disrupts the interaction between p53 and Morn3-mediated complex, Morncide peptide stabilizes and reactivates p53 in cancer cells.

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1 g		Get quote

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生物&药学活性

Morncide (Morn3 (222-237)) is a cell-penetrating, 16-AA Morn3-targeting peptide that disrupts the interaction between p53 and Morn3-mediated complex, Morncide peptide stabilizes and reactivates p53 in cancer cells.
Morncide (CPP-Morn3 (222-237)) efficiently increases p53 expression and acetylation, causing substantial decrease in p53 ubiquitination in cultured CRC cells, displays dose-dependent upregulation of CDKN1A, BAX, and NOXA.
Morncide increases p53 expression and acetylation, causing significant induction of p21 expression in tumor tissue, decreases tumor growth in mice carrying HCT116 (wild-type p53) xenograft tumors.
The Morn3 gene encodes a MORN (membrane occupation and recognition nexus) repeats-containing protein that is 240 amino acids in length.
Morn3 is a cancer/testis antigen with oncogenic functions, assembles a protein complex to regulate composite modifications of p53.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sequence: PDGVL AEALA MFRKT E

参考文献

1. Lunxi Liang, et al. Cell Chem Biol. 2018 Jun 21;25(6):761-774.e5.

Morncide (CPP-Morn3 (222-237))

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物理化学性质&存储条件

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Morncide (CPP-Morn3 (222-237))

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物理化学性质&存储条件

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