Montelukast sodium (MK0476) | LTD4 receptor inhibitor

Chemical Structure : Montelukast sodium

CAS No.: 151767-02-1

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Montelukast sodium (MK0476, MK-0476)

货号: PC-43487Not For Human Use, Lab Use Only.

Montelukast sodium (MK0476, MK-0476) is a potent, selective, orally active leukotriene D4 (LTD4) receptor (CysLT1 receptor) antagonist with Ki of 0.18 nM for guinea pig lung LTD4.

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50 mg	￥580	In stock
100 mg	￥980	In stock
500 mg	￥1880	In stock
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生物&药学活性

Montelukast sodium (MK0476, MK-0476) is a potent, selective, orally active leukotriene D4 (LTD4) receptor (CysLT1 receptor) antagonist with Ki of 0.18 nM for guinea pig lung LTD4.
Montelukast sodium (MK0476) shows no significant affinity for leukotriene C4 and leukotriene B4 receptors.
Montelukast sodium (MK0476) is a potent and competitive antagonist of leukotriene D4-induced contractions of non-tonal guinea-pig trachea with pA2 of 9.3.
Montelukast sodium (MK0476) antagonizes bronchoconstriction induced in anesthetized guinea pigs by i.v. leukotriene D4, blocks leukotriene D4 induced bronchoconstriction in vivo.

物理化学性质&存储条件

分子量	608.17
分子式	C35H35ClNNaO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	H2O: ≥ 70 mg/mL
Chemical Name/SMILES	Cyclopropaneacetic acid, 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, sodium salt (1:1)

参考文献

1. Jones TR, et al. Can J Physiol Pharmacol. 1995 Feb;73(2):191-201.

Montelukast sodium (MK0476, MK-0476)

生物&药学活性

物理化学性质&存储条件

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Montelukast sodium (MK0476, MK-0476)

生物&药学活性

物理化学性质&存储条件

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