Monastrol |CAS:329689-23-8 Probechem Biochemicals

Chemical Structure : Monastrol

CAS No.: 329689-23-8

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Monastrol ((±)-Monastrol)

货号: PC-42308Not For Human Use, Lab Use Only.

Monastrol is a potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).

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生物&药学活性

Monastrol is a potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
Monastrol does not inhibit microtubule motility driven by conventional kinesin at 200 uM.
Monastrol inhibits both the basal and the microtubule-stimulated ATPase activity of the Eg5 motor domain, does not compete with ATP binding to Eg5; arrests cells in mitosis with monoastral spindles.
(S)-monastrol is a more potent inhibitor of Eg5 activity in vitro and in vivo.

物理化学性质&存储条件

分子量	292.35344
分子式	C14H16N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester

参考文献

1. Mayer TU, et al. Science. 1999 Oct 29;286(5441):971-4.

2. Kapoor TM, et al. J Cell Biol. 2000 Sep 4;150(5):975-88.

3. DeBonis S, et al. Biochemistry. 2003 Jan 21;42(2):338-49.

4. Maliga Z, et al. Chem Biol. 2002 Sep;9(9):989-96.

Monastrol ((±)-Monastrol)

生物&药学活性

物理化学性质&存储条件

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Monastrol ((±)-Monastrol)

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