Chemical Structure : Monalizumab
CAS No.: 1228763-95-8
货号: PC-Ab1087Not For Human Use, Lab Use Only.
Monalizumab (IPH2201) is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. The first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells. NKG2A is an inhibitory checkpoint receptor for HLA-E. Monalizumab targets NKG2A receptors expressed on tumor infiltrating cytotoxic CD8 T lymphocytes and NK cells. NKG2A is an inhibitory receptor binding HLA-E. By expressin
规格 | 价格 | 库存 | 数量 |
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1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Monalizumab (IPH2201) is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. The first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells. NKG2A is an inhibitory checkpoint receptor for HLA-E. Monalizumab targets NKG2A receptors expressed on tumor infiltrating cytotoxic CD8 T lymphocytes and NK cells. NKG2A is an inhibitory receptor binding HLA-E. By expressing HLA-E, cancer cells can protect themselves from killing by NKG2A+ immune cells.
分子量 | ||
分子式 | Human IgG4-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Monalizumab; IPH2201; IPH 2201; anti human NKG2A; anti human CD159Aa; anti human KLRC1; 1228763-95-8 |
1. 1, van Hall T, et al. J Immunother Cancer. 2019 Oct 17;7(1):263. 2, André P, et al. Cell. 2018 Dec 13;175(7):1731-1743.e13. 3, Borst L, et al. Clin Cancer Res. 2020 Nov 1;26(21):5549-5556. 4, Tinker AV, et al. Clin Cancer Res. 2019 Oct 15;25(20):6052-6060. 5, Yaqinuddin A, et al. Med Hypotheses. 2020 Apr 22;140:109777.
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