Mocetinostat (MGCD0103) | class I HDAC inhibitor | Probechem Biochemicals

Chemical Structure : Mocetinostat

CAS No.: 726169-73-9

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Mocetinostat (MGCD0103, MGCD-0103)

货号: PC-42903Not For Human Use, Lab Use Only.

Mocetinostat (MGCD0103) is an isotype-selective small molecule class I HDAC inhibitor with IC50 of 0.15/0.29/1.66 uM for HDAC1/2/3.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
250 mg		Get quote

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生物&药学活性

Mocetinostat (MGCD0103) is an isotype-selective small molecule class I HDAC inhibitor with IC50 of 0.15/0.29/1.66 uM for HDAC1/2/3.
Mocetinostat (MGCD0103) also inhibits HDAC11 (IC50=0.59 uM), but has no effect on HDAC4/5/6/7/8.
Mocetinostat (MGCD0103) induces hyperacetylation of histones and caused cell cycle blockade in various human cancer cell lines.
Mocetinostat (MGCD0103) inhibits growth of human tumor xenografts in nude mice.
Mocetinostat (MGCD0103) is orally bioactive.

物理化学性质&存储条件

分子量	396.4445
分子式	C23H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-

参考文献

1. Fournel M, et al. Mol Cancer Ther. 2008 Apr;7(4):759-68.

2. Zhou N, et al. J Med Chem. 2008 Jul 24;51(14):4072-5.

3. Raeppel S, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):644-9.

Mocetinostat (MGCD0103, MGCD-0103)

生物&药学活性

物理化学性质&存储条件

参考文献

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Mocetinostat (MGCD0103, MGCD-0103)

生物&药学活性

物理化学性质&存储条件

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