Mocetinostat |CAS:726169-73-9 Probechem Biochemicals

Chemical Structure : Mocetinostat

CAS No.: 726169-73-9

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Mocetinostat (MGCD0103;MGCD 0103;MGCD-0103)

货号: PC-42903Not For Human Use, Lab Use Only.

Mocetinostat (MGCD-0103) is an isotype-selective small molecule HDAC inhibitor that selectively inhibits HDAC1 (IC50=0.15 uM).

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100 mg	￥3580	In stock
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生物&药学活性

Mocetinostat (MGCD-0103) is an isotype-selective small molecule HDAC inhibitor that selectively inhibits HDAC1 (IC50=0.15 uM).
Mocetinostat (MGCD-0103) also inhibits HDAC2/3/11, but has no effect on HDAC4/5/6/7/8.
Mocetinostat (MGCD-0103) induces hyperacetylation of histones and caused cell cycle blockade in various human cancer cell lines.
Mocetinostat (MGCD-0103) inhibits growth of human tumor xenografts in nude mice.
Mocetinostat (MGCD-0103) is orally bioactive.

物理化学性质&存储条件

分子量	396.4445
分子式	C23H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-

参考文献

1. Fournel M, et al. Mol Cancer Ther. 2008 Apr;7(4):759-68.

2. Zhou N, et al. J Med Chem. 2008 Jul 24;51(14):4072-5.

3. Raeppel S, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):644-9.

Mocetinostat (MGCD0103;MGCD 0103;MGCD-0103)

生物&药学活性

物理化学性质&存储条件

参考文献

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Mocetinostat (MGCD0103;MGCD 0103;MGCD-0103)

生物&药学活性

物理化学性质&存储条件

参考文献

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