Mobocertinib (TAK-788) | EGFR Ex20Ins inhibitor | Probechem Biochemicals

Chemical Structure : Mobocertinib

CAS No.: 1847461-43-1

加入收藏

Mobocertinib (TAK-788, AP32788, TAK788)

货号: PC-73153Not For Human Use, Lab Use Only.

Mobocertinib (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM.

规格	价格	库存
25 mg	￥680	In stock
50 mg	￥980	In stock
100 mg	￥1580	In stock
500 mg	￥3580	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Mobocertinib (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM.
Mobocertinib (TAK-788) displays selectivity over WT EGFR (IC50=34.5 nM).
Mobocertinib (TAK-788) inhibited all five variants of EGFR ex20ins mutations with IC50 of 4.3 nM for NPG, 10.9 nM for ASV, 11.8 nM for A763_Y764insFQEA (FQEA), 18.1 nM for N771_H773dupNPH (NPH), and 22.5nM for S768_D770dupSVD.
Mobocertinib (TAK-788) inhibited viability of various EGFRex20ins-driven cell lines more potently (CUTO14 cell viability assay, IC50=33 nM) than approved EGFR TKIs and demonstrated in vivo antitumor efficacy in patient-derived xenografts and murine orthotopic models.

物理化学性质&存储条件

分子量	585.709
分子式	C32H39N7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (5.85 mg/mL)
Chemical Name/SMILES	Isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate

参考文献

1. Han H, et al. Cancer Res. 2021 Oct 15;81(20):5311-5324.

2. Zhang SS, et al. Lung Cancer (Auckl). 2021 Jul 12;12:61-65.

3. Gonzalvez F, et al. Cancer Discov. 2021 Jul;11(7):1672-1687.

Mobocertinib (TAK-788, AP32788, TAK788)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Mobocertinib (TAK-788, AP32788, TAK788)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.