Mivebresib |CAS:1445993-26-9 Probechem Biochemicals

Chemical Structure : Mivebresib

CAS No.: 1445993-26-9

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Mivebresib (ABBV-075;ABBV075)

货号: PC-42029Not For Human Use, Lab Use Only.

Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4780	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively.
Mivebresib (ABBV-075) displays 54-fold selectivity over EP300, has potential weak activity against SMARCA4 (70% inhibition at 1 uM), Kd >1 uM for 18 other bromodomains.
Mivebresib (ABBV-075) exhibits inhibition of c-Myc expression and displacing BRD4 from the Myc promoter.
Mivebresib (ABBV-075) dose-dependently inhibits IL-6 concentration in a murine model of LPS-induced endotoxic shock, shows vivo antitumor efficacy in a Kasumi-1 AML mouse xenograft model.

物理化学性质&存储条件

分子量	459.4658
分子式	C22H19F2N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 37 mg/mL
Chemical Name/SMILES	Ethanesulfonamide, N-[4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-

参考文献

1. McDaniel KF, et al. J Med Chem. 2017 Oct 26;60(20):8369-8384.

Mivebresib (ABBV-075;ABBV075)

生物&药学活性

物理化学性质&存储条件

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Mivebresib (ABBV-075;ABBV075)

生物&药学活性

物理化学性质&存储条件

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