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首页-小分子抑制剂&激动剂-Others-Other Targets-Mitoquinone mesylate
Mitoquinone mesylate

Chemical Structure : Mitoquinone mesylate

CAS No.: 845959-50-4

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Mitoquinone mesylate (MitoQ)

货号: PC-21381Not For Human Use, Lab Use Only.

Mitoquinone mesylate (MitoQ) is a potent inhibitor of TRAP1 activity in cancer cells with IC50 of 0.2 uM in 22Rv1 cells, reduces SDHB and SIRT3 and increases phosphor-AMPK and CHOP.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
50 mg ￥5680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mitoquinone mesylate (MitoQ) is a potent inhibitor of TRAP1 activity in cancer cells with IC50 of 0.2 uM in 22Rv1 cells, reduces SDHB and SIRT3 and increases phosphor-AMPK and CHOP.
MitoQ potently disrupted the mitochondrial membrane potential (TMRM staining) and elevated ROS production (Mito-SOX staining) and consequently induced mitochondrial fragmentation and elevated cytoplasmic calcium levels in cancer cells.
MitoQ, in combination with mitoquinol, reduces malondialdehyde (MDA) levels in isolated rat liver mitochondria and decreases caspase activity in Jurkat cells.
MitoQ alleviates retinal pathologies via proteolytic HIF1α degradation, which is mediated by opening of the mitochondrial permeability transition pore and activation of calcium-dependent protease calpain-1.

物理化学性质&存储条件

分子量 678.81
分子式 C38H47O7PS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl)triphenylphosphonium methanesulfonate

参考文献

1. So-Yeon Kim, et al. Adv Sci (Weinh). 2023 Nov 20:e2302776.

2. Kelso GF, et al. Ann N Y Acad Sci. 2002.

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