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首页-小分子抑制剂&激动剂-Others-Other Targets-Mitochonic acid 5
Mitochonic acid 5

Chemical Structure : Mitochonic acid 5

CAS No.: 1354707-41-7

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Mitochonic acid 5 (MA-5)

货号: PC-24789Not For Human Use, Lab Use Only.

Mitochonic acid 5 (MA-5) is a synthesized indole derivative targeting the mitochondrial protein mitofilin, modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mitochonic acid 5 (MA-5) is a synthesized indole derivative targeting the mitochondrial protein mitofilin, modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain.
Mitochonic acid 5 (MA-5) facilitates ATP production and reduces the level of mitochondrial reactive oxygen species (ROS) without affecting activity of mitochondrial complexes I-IV.
MA-5 facilitates mitochondrial ATP production and reduces ROS independent of ETC by facilitating ATP synthase oligomerization and supercomplex formation with mitofilin/Mic60. 
Mitochonic acid 5 (MA-5) improves renal function in an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model. In Hep3B cells.
Overexpression of mitofilin increased the basal ATP level, and treatment with MA-5 amplified it's effect.
Mitochonic acid 5 (MA-5) improves the reduced cardiac and renal mitochondrial respiration and seems to prolong survival in unique mitochondrial disease model (Mitomice with mitochondrial DNA deletion that mimics typical human mitochondrial disease phenotype).
Mitochonic acid 5 (MA-5) increases cellular ATP level and survival of fibroblasts from patients with mitochondrial disease.

物理化学性质&存储条件

分子量 329.30
分子式 C18H13F2NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid

参考文献

1. Suzuki T, et al. Tohoku J Exp Med. 2015 Jul;236(3):225-32.

2. Suzuki T, et al. J Am Soc Nephrol. 2016 Jul;27(7):1925-32.

3. Matsuhashi T, et al. EBioMedicine. 2017 Jun;20:27-38.

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