MitoBloCK-10 |CAS:394694-98-5 Probechem Biochemicals

Chemical Structure : MitoBloCK-10

CAS No.: 394694-98-5

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MitoBloCK-10 (MB-10)

货号: PC-35922Not For Human Use, Lab Use Only.

MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway.

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生物&药学活性

MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway.
MitoBloCK-10 targets Tim44 and mutations in the α4 helix of the C-terminal domain of Tim44 confer resistence to MitoBloCK-10 (MB-10).
MitoBloCK-10 (MB-10) inhibits Tim44 binding to the precursor and to Hsp70, but not other component of the PAM complex.
MitoBloCK-10 inhibits Hela cell viability with IC50 of 17.2 uM in MTT assays, impairs cardiac development and induces apoptosis in zebrafish.

物理化学性质&存储条件

分子量	293.272
分子式	C12H8FN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide

参考文献

1. Conti, M. (2018). Small Molecule Probes of Mitochondrial Translocases Elucidate PINK1 Trafficking in PINK1/Parkin Regulated Mitophagy. UCLA.

2. Miyata N, et al. J Biol Chem. 2017 Mar 31;292(13):5429-5442.

MitoBloCK-10 (MB-10)

生物&药学活性

物理化学性质&存储条件

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MitoBloCK-10 (MB-10)

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