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Mito-LND

Chemical Structure : Mito-LND

CAS No.: 2361564-49-8

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Mito-LND (Mito-lonidamine)

货号: PC-21018Not For Human Use, Lab Use Only.

Mito-LND (Mito-lonidamine) is a tumor-selective inhibitor of oxidative phosphorylation with IC50 of 1.2 and 2.4 uM for mitochondrial complexes I and II, respectively, impacts the activity of mitochondrial complexes, ROS generation and peroxiredoxin oxidation.

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25 mg ￥8980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mito-LND (Mito-lonidamine) is a tumor-selective inhibitor of oxidative phosphorylation with IC50 of 1.2 and 2.4 uM for mitochondrial complexes I and II, respectively, impacts the activity of mitochondrial complexes, ROS generation and peroxiredoxin oxidation.
Mito-LND shows 100-fold more potent than lonidamine (LND).
Mito-LND inhibits mitochondrial bioenergetics in lung cancer cells and mitigates lung cancer cell viability, growth, progression, and metastasis of lung cancer xenografts in mice.
Mito-LND blocks lung tumor development and brain metastasis by inhibiting mitochondrial bioenergetics, stimulating the formation of reactive oxygen species, oxidizing mitochondrial peroxiredoxin, inactivating AKT/mTOR/p70S6K signaling, and inducing autophagic cell death in lung cancer cells.
Mito-LND is selective for cancer cells and tumor tissue, does not induce autophagy in normal lung and brain tissue or normal lung cell lines.

物理化学性质&存储条件

分子量 801.63
分子式 C43H45BrCl2N3OP
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Phosphonium, [10-[[[1-[(2,4-dichlorophenyl)methyl]-1H-indazol-3-yl]carbonyl]amino]decyl]triphenyl-, bromide (1:1)

参考文献

1. Gang Cheng, et al. Nat Commun. 2019 May 17;10(1):2205.

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