Mirogabalin besylate |CAS:1138245-21-2 Probechem Biochemicals

Chemical Structure : Mirogabalin besylate

CAS No.: 1138245-21-2

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Mirogabalin besylate (DS-5565;DS5565)

货号: PC-50011Not For Human Use, Lab Use Only.

Mirogabalin besylate (DS-5565) is a novel potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively.

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10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3780	In stock
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生物&药学活性

Mirogabalin besylate (DS-5565) is a potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively.
Mirogabalin besylate (DS-5565) exhibits a slower dissociation rate for the α2δ-1 subunit than the α2δ-2 subunit compared to pregabalin.
Mirogabalin besylate (DS-5565) shows more potent and longer lasting analgesic effects in experimental neuropathic pain models, partial sciatic nerve ligation rats and streptozotocin-induced diabetic rats.
Mirogabalin besylate (DS-5565) inhibits rota-rod performance and locomotor activity in rats.

物理化学性质&存储条件

分子量	367.46
分子式	C18H25NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1)

参考文献

1. Merante D, et al. Pain Med. 2017 Nov 1;18(11):2198-2207.

2. Vinik A, et al. Diabetes Care. 2014 Dec;37(12):3253-61.

3. Domon Y, et al. J Pharmacol Exp Ther. 2018 Mar 21. pii: jpet.117.247551.

Mirogabalin besylate (DS-5565;DS5565)

生物&药学活性

物理化学性质&存储条件

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Mirogabalin besylate (DS-5565;DS5565)

生物&药学活性

物理化学性质&存储条件

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