Mirk-IN-1 | DYRK1A/1B inhibitor | Probechem Biochemicals

Chemical Structure : Mirk-IN-1

CAS No.: 1386979-55-0

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Mirk-IN-1 (Dyrk1B/A-IN-1)

货号: PC-43249Not For Human Use, Lab Use Only.

Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM.
Mirk-IN-1 weakly inhibits DYRK1A, ABL, FLT3, and MARK1 with 88%, 64%, 56% and 73% at 10 uM, shows no activity against the other kinases in the Caliper assay panel.
Mirk-IN-1 blocks tumor cells from undergoing reversible arrest in a quiescent G(0) state and enables some cells to exit quiescence, elevates ROS levels and DNA damage detected by increased phosphorylation of the histone protein H2AX and by S-phase checkpoints.
Mirk-IN-1 sensitizes cells to gemcitabine and cisplatin.

物理化学性质&存储条件

分子量	498.3182
分子式	C23H17Cl2N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[2-chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxo-

参考文献

1. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14.

2. Anderson K, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.

Mirk-IN-1 (Dyrk1B/A-IN-1)

生物&药学活性

物理化学性质&存储条件

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Mirk-IN-1 (Dyrk1B/A-IN-1)

生物&药学活性

物理化学性质&存储条件

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