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首页-小分子抑制剂&激动剂-Others-Amyloids-Miridesap
Miridesap

Chemical Structure : Miridesap

CAS No.: 224624-80-0

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Miridesap (Ro 638695, GSK2315698, CPHPC)

货号: PC-63132Not For Human Use, Lab Use Only.

Miridesap (Ro 638695, GSK-2315698, CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils.

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10 mg ￥780 In stock
25 mg ￥1180 In stock
50 mg ￥1880 In stock
100 mg ￥2980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Miridesap (Ro 638695, GSK-2315698, CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils.
Miridesap crosslinks and dimerizes SAP molecules, leading to their very rapid clearance by the liver, and thus produces a marked depletion of circulating human SAP.
Miridesap is a novel therapeutic approach to both systemic amyloidosis and diseases associated with local amyloid, including Alzheimer's disease and type 2 diabetes.

物理化学性质&存储条件

分子量 340.376
分子式 C16H24N2O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline

参考文献

1. Kolstoe SE, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23.

2. Pepys MB, et al. Nature. 2002 May 16;417(6886):254-9.

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